Acute generalized exanthematous pustulosis
Tha Acute generalized exanthematous pustulosis (AGEP) na ath-bhualadh craiceann tearc a tha ann an 90% de chùisean co-cheangailte ri rianachd cungaidh-leigheis. Tha acute generalized exanthematous pustulosis air a chomharrachadh le sprèadhadh craiceann obann a nochdas gu cuibheasach còig latha às deidh cungaidh-leigheis a thòiseachadh. Is e pustules a th’ anns na sprèadhaidhean sin, i.e. sprèadhadh beag dearg geal no dearg den chraiceann anns a bheil stuth sgòthach no purulent (pus). Mar as trice bidh lotan craiceann a’ fuasgladh taobh a-staigh 1-3 latha bho stad a’ chungaidh-leigheis oilbheumach.
☆ Ann an toraidhean 2022 Stiftung Warentest às a’ Ghearmailt, cha robh sàsachd luchd-cleachdaidh le ModelDerm ach beagan nas ìsle na le co-chomhairlean telemedicine pàighte.
Bidh leòintean farsaing le erythema agus pustules a’ nochdadh gu h-obann.
References
Is e ath-bhualadh craiceann a th’ ann an Acute generalized exanthematous pustulosis (AGEP) air a chomharrachadh le cnapan beaga làn pus air bonn craiceann dearg. Mar as trice bidh e a’ tachairt nuair a bheir cuideigin cungaidhean sònraichte, leithid antibiotics, agus gu luath a’ sgaoileadh air feadh a’ chuirp. Às deidh stad a chuir air a’ chungaidh-leigheis brosnachaidh, mar as trice bidh na comharraidhean a ’falbh taobh a-staigh dà sheachdain, gu tric a’ fàgail beagan rùsgadh craiceann. Ged nach àbhaist dhaibh a bhith dona agus cuingealaichte ris a’ chraiceann, faodar cùisean cruaidh a chomharrachadh còmhla ri droch ath-bhualaidhean craiceann leithid Stevens-Johnson syndrome no toxic epidermal necrolysis. Tha làimhseachadh gu ìre mhòr na chùram taiceil, agus mar as trice tha an prognosis airson fuasgladh iomlan den ghalar sàr-mhath.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Thàinig fireannach, 76, dhan t-seòmar-èiginn leis gu robh a chraiceann air atharrachadh thairis air an dà latha a dh'fhalbh. Lorg dotairean badan dearga agus raointean àrdaichte air a stoc agus a ghàirdeanan agus a chasan. Mar a chaidh an ùine air adhart, thàinig na pìosan sin còmhla, agus leasaich e cnapan coltach ri pimple anns na raointean dearga. Sheall deuchainnean cunntadh ceallan fala geal àrd le tòrr de sheòrsa ris an canar neutrophils, agus ìrean nas àirde de C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
